Successful Treatment of Mucous Membrane Pemphigoid with the Anti-CD-20 Antibody Rituximab
نویسندگان
چکیده
منابع مشابه
Successful treatment of mucous membrane pemphigoid with the anti-CD-20 antibody rituximab.
101 Letters to the Editor Sir, Mucous membrane pemphigoid (MMP) is an often difficult to treat autoimmune bullous disease characterized by circulating auto-antibodies targeting the dermo-epidermal junctional zone (1–3). Due to limited disease control and/or severe adverse reactions to glucocorticoids and conventional immunosuppressants, alternative treatment options are frequently needed. We de...
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BP: bullous pemphigoid MMP: mucous membrane pemphigoid INTRODUCTION Mucous membrane pemphigoid (MMP) is a rare, autoantibody-mediated disease characterized by mucocutaneous blistering including oral, ocular, laryngeal, and skin involvement. Treating MMP is challenging, with few effective therapies available. We report successful treatment of a patient with treatment-refractory MMP with the prot...
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Our patient was diagnosed with cicatricial pemphigoid (CP) in 2001. She demonstrated classic clinical findings and underwent biopsies that supported this diagnosis. She unfortunately experienced severe CP involving both of her eyes, oral mucosa, pharyngeal mucosa, and esophagus. Her left eye was seriously affected early in the course of her disease. She experienced significant scarring of the c...
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BACKGROUND Mucous membrane pemphigoid (MMP) still represents a potentially life- and sight-threatening disease. In a subset of patients with severe MMP, conventional immunosuppressants are ineffective or contraindicated. OBSERVATIONS Twenty-five patients with severe refractory MMP, including 5 with mucous membrane-dominant epidermolysis bullosa acquisita, received 1 or 2 cycles of rituximab (...
متن کاملTreatment strategies in mucous membrane pemphigoid
Mucous membrane pemphigoid (MMP) is an autoimmune blistering disorder that is characterized by subepithelial bullae. Various basement membrane zone components have been identified as targets of autoantibodies in MMP. Considerable variability exists in the clinical presentation of MMP. Mucous membranes that may be involved include the oral cavity, conjunctiva, nasopharynx, larynx, esophagus, gen...
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ژورنال
عنوان ژورنال: Acta Dermato Venereologica
سال: 2009
ISSN: 0001-5555
DOI: 10.2340/00015555-0560